Bradley E. Bernstein MD, PhD

Bradley E. Bernstein is an institute member at the Broad Institute and a professor in the Department of Pathology at Massachusetts General Hospital and Harvard Medical School. He co-directs the Broad’s Epigenomics Program and interacts extensively with the Cell Circuits Program, the Cancer Program, and the Klarman Cell Observatory.

Bernstein’s research focuses on epigenetics — changes in gene activity governed by influences outside the genes themselves — and specifically how modifications to the protein scaffold called chromatin contribute to mammalian development and human cancer. Bernstein’s laboratory is characterizing epigenetic mechanisms that underlie stem cells’ ability to give rise to almost any kind of cell, while also exploring how epigenetic mechanisms contribute to malignant transformation and therapeutic resistance.