Dr. Frank Liu has close to 10 years’ experience in chemical risk assessment and safety evaluation, many years of solid research experience, significant publication and paper review experience and successful NIH grant application record in DNA and telomere damage and repair and general toxicology. After his master’s and PhD education in environmental toxicology and two postdoctoral trainings in pharmaceutical sciences and human toxicology, Frank moved to the product safety assessment area in the personal care and pharmaceutical product industries. Currently, he leads the pharmaceutical risk assessment and safety evaluation team responsible for patient, environmental and occupational safety at Takeda. One of his major focusses and capabilities is to perform safety assessments of impurities such as extractables, leachables, intermediates, catalysts, particulate matters and of genotoxic, elemental and solvent impurities using classic and alternative approaches (e.g., read-across, in silico, QSAR and TTC).