Jennifer Trittmann MD, MPH

Jennifer Trittmann, MD, MPH, is the Principal Investigator, at the Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children’s Hospital and an Assistant Professor in the Division of Neonatology, Department of Pediatrics at The Ohio State University College of Medicine. Dr. Trittmann’s research focuses on bronchopulmonary dysplasia (BPD)-associated pulmonary hypertension (PH), a life-threatening neonatal disease characterized by progressive pulmonary vascular endothelial dysfunction and smooth muscle cell proliferation. Currently, there are no available predictive biomarkers or curative therapies for BPD-PH. Our labs at the Abigail Wexner Research Institute have discovered genetic and biochemical markers for BPD-PH including single polymorphisms in arginase-1 (ARG1), dimethylarginine dimethylaminohydrolase-1 (DDAH1), dual specificity phosphatase-1&5 (DUSP1&5), and plasma levels of asymmetric dimethylarginine (ADMA). Our group has developed endothelial DDAH1 conditional knockout mice for studies after intrauterine inflammation (LPS) and post-natal hyperoxia exposure, a disease model for BPD-PH.