Karin R. Engelhardt is a Research Associate in the research group of Prof. Sophie Hambleton on a five-year project funded by a Wellcome Trust Investigator Award to Prof. Hambleton, “The Troubled Immune System: Molecular Origins of Early Onset Immune Dysregulation”. She is responsible for the oversight and delivery of research described in this proposal, specifically the validation and mechanistic exploration of novel genetic variants implicated in primary immunodeficiency disease. She contributes to the dissemination of results through presentations to clinicians and other researchers and the writing up of the findings in clinical reports. She has a co-supervisory role for a Ph.D. student and is involved in the supervision of final-year undergraduate research projects.