Born in South Africa, Dr. Seeff attended and graduated from the Medical School of the University of the Witwatersrand, Johannesburg, South Africa in 1961. He came to the United States in late 1964 to work with Dr. Hyman J. Zimmerman, then Chief of the Department of Medicine, Mount Sinai Hospital, Chicago, Illinois and Chairman of the Department of Medicine, Mount Sinai Medical School. Dr. Zimmerman, one of the founders of the discipline of Hepatology, was a revered teacher, mentor, administrator and clinical researcher, and also this country's leading expert in the area of hepatotoxicity .